A DNA damage response-like phenotype defines a third of colon cancers at onset. Supplementary data.
These are supplemental data to the manuscript entitled: A DNA damage response-like phenotype defines a novel subset of colon cancer. A third of de-novo presentations of colorectal cancer display foci of positivity for ℽH2AX, pCHK2, pNBS1 in the absence of apoptosis or senescence associated p21/CDKN1A. This phenotype is reminiscent of an ongoing DNA damage response (DDR). The TP53 status, the chromosome 20q amplification or the microsatellite instability gene status did not correlate with the DDR phenotype, except for a preferential association with MSH2/MSH6 inactivation and conserved MLH1. Additional lesions of DDR-associated genes may be responsible for this phenotype, which is absent from the remaining cases in this cohort. The outcome, after adjuvant treatment with DNA-damaging drugs, did not differentiate this group from the remaining cases. DDR+ colorectal cancers may be amenable to personalized therapy by targeting the DDR.
IMMUN-HUB - Sviluppo di nuove molecole di seconda generazione per immunoterapia oncologica (2019-NAZ-0120)
Additional Metadata for University of Milano - Bicocca
|Date the data was collected||2021-12-17T00:00:00.000Z|
|ERC Keywords||LS1_3 DNA synthesis, modification, repair, recombination, degradation, LS7_3 Other medical technologies for diagnosis and monitoring of diseases, LS2_9 Proteomics, LS3_6 Cell cycle, division and growth, LS4_6 Fundamental mechanisms underlying cancer|
|SSD Classification||MED/08 - ANATOMIA PATOLOGICA, MED/01 - STATISTICA MEDICA, MED/04 - PATOLOGIA GENERALE|