Holotomographic microscopy - Halting the Reverse Mode: NCX Inhibition as a Neuroprotective Strategy against Oxaliplatin-Induced Peripheral Neurotoxicity

Name: Holotomographic microscopy - Halting the Reverse Mode: NCX Inhibition as a Neuroprotective Strategy against Oxaliplatin-Induced Peripheral Neurotoxicity
Creator: Paola Alberti
Published: 2026-07-14T06:15:00.728Z
Keywords: File Backup

Alberti, Paola

doi:10.17632/c9z6v6z86b.1

Holotomographic microscopy - Halting the Reverse Mode: NCX Inhibition as a Neuroprotective Strategy against Oxaliplatin-Induced Peripheral Neurotoxicity

Published: 14 July 2026| Version 1 | DOI: 10.17632/c9z6v6z86b.1

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Description

Live-cell holotomographic imaging of OHP-induced pathological changes in DRG neurons. These videos show primary adult mouse DRG neuronal cultures exposed to OHP at 7.5 or 25 µM. Refractive index-based imaging captures neurite fragmentation and degeneration, morphological features consistent with necroptosis, and autophagic vacuoles. Images were acquired using a 5 × 5 grid scan, with each grid measuring 90 × 90 µm, every 15 min for 28 h at 7 fps, from 24 to 52 h after OHP incubation.

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University of Milano-Bicocca
Lombardy, Milan

Departments

School of Medicine and Surgery

Additional Metadata for University of Milano - Bicocca

Language	English
Date the data was collected	2026-02-04T23:00:00.000Z
SSD Classification	BIO/16 - ANATOMIA UMANA

Holotomographic microscopy - Halting the Reverse Mode: NCX Inhibition as a Neuroprotective Strategy against Oxaliplatin-Induced Peripheral Neurotoxicity

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Additional Metadata for University of Milano - Bicocca

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